Antimicrobial substituted thiazoles and methods of use
AssigneePurdue Research Foundation
InventorsMark Stanley Cushman, Mohamed Seleem, Abdelrahman S. Mayhoub
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Abstract
Disclosed are compositions having activity against MRSA and/or VRSA, and methods of using the compositions to treat microbial infections.
Claims14
A method of treating a microbial infection in a subject comprising administering to the subject a pharmaceutical composition in an amount effective to treat the infection, the pharmaceutical composition comprising a compound having the chemical structure:
- wherein Z consists of a cationic moiety and optionally a linker through which the cationic moiety is attached to the thiazole ring, Y is a lipophilic moiety that is not an alkyl and not an alkoxy, and R consists of H or any suitable substituent, wherein the compound has antimicrobial activity, and wherein the compound does not substantially disrupt bacterial cell membranes.
The method of claim 1, wherein Y is a cycloalkyl, aryl, cycloalkenyl, aryloxy, alkylthio, arylthio, amino, heteroaryl, acyl, phenyl, naphthyl, benzoyl, amide, heteroaryl, alkynyl, alkenyl, arylalkyl, arylalkynyl, arylalkenyl, haloalkyl, thioamide, nitro, ester, or carbamate. The method of claim 6, wherein Y is 4-acetylphenyl, 4-fluorophenyl, 4-trifluoromethylphenyl, 2-naphthyl, 3-fluorophenyl, or 3,5-dimethoxyphenyl.
Dependencies are inferred from the claim text.