Sustained Release Formulations Containing Methylglyoxal and Their Therapeutic Applications

A process for the preparation of a nano drug formulation comprising:

• preparing a homogenous solution of nanoparticles, dendrimers of biodegradable synthetic polymers, natural polymers and their derivatives;
• adding methylglyoxal solution to the homogenous solution to form a reaction mixture;
• adding a surfactant to the reaction mixture;
• subjecting the reaction mixture and surfactant to the step of stirring/mixing;
• adding sodium sulfate to the surfactant and reaction mixture under stirring/mixing;
• adding a crosslinking agent and sodium metabisulphite to the solution;
• and
• subjecting the solution to the step of filtration.

A method of treating a metastasis, infection, or immune disorder comprising administering to a patient in need thereof a composition comprising:

• 0.125-0.5 mg of methylglyoxal encapsulated by or conjugated to nanoparticles, dendrimers of biodegradable synthetic polymers, natural polymers and their derivatives;
• 0.125-0.5 mg of melatonin;
• 75-300 mg of creatine;
• and
• 25-100 mg of ascorbic acid,
• wherein all constituents are meant for each kg of body weight.