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US 2016/0243049 A1Published application
Nanoraspberries for photothermal cancer therapy
AssigneeWashington University
InventorsSrikanth Singamaneni, Naveen Gandra, Christopher Portz
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Abstract
Compositions and methods for cancer therapy are disclosed. More particularly, the present disclosure relates to tumor-selective chitosan protected gold nanoraspberries for photothermal cancer therapy.
Claims20
A composition comprising:
- a plurality of gold nanoparticles;
- and a chitosan-coating surrounding the plurality of gold nanoparticles, wherein the composition has a raspberry-like morphology.
A method of preparing a plurality of chitosan-coated gold nanoraspberries, the method comprising:
- forming a growth solution, wherein the growth solution is prepared by providing a chitosan solution;
- adding to the chitosan solution a solution comprising gold chloride (HAuCl4);
- adding a solution comprising silver nitrate (AgNO3) to the chitosan solution;
- adding ascorbic acid;
- and incubating the growth solution for a sufficient time to form the plurality of chitosan-coated gold nanoraspberries.
2 more elements
A method of photothermal cancer treatment in a subject having or suspected of having a cancer tumor, the method comprising:
- administering a plurality of chitosan-coated gold nanoraspberries to the subject;
- incubating the subject for a sufficient period of time to allow for internalization of the chitosan-coated gold nanoraspberries by cells of the cancer tumor;
- and exposing the cancer tumor to laser irradiation.
Dependencies are inferred from the claim text.