Tissue Prostheses for Repairing, Reconstructing and Replacing Damaged or Diseased Biological Structures and Associated Tissue

A method for reconstructing and replacing damaged biological structures and tissue, comprising the steps of:

• providing a tissue prosthesis comprising a seamless tubular member, said seamless tubular member comprising a decellularized mammalian tubular structure, said tubular structure having a first length, proximal and distal ends, an outer surface and a lumen that extends therethrough,
• said mammalian tubular structure further comprising at least one coating, said coating comprising poly(glycerol sebacate) (PGS), said PGS coating being disposed on at least a portion of said tubular structure outer surface,
• said coated mammalian tubular structure being configured to induce modulated healing when said tubular member is disposed proximate damaged biological tissue of a biological structure, said modulated healing comprising modulation of inflammation of said damaged tissue, host tissue proliferation, bioremodeling of said damaged tissue, and regeneration of new tissue and tissue structures with site-specific structural and functional properties;
• and
• disposing said tissue prosthesis proximate said damaged biological tissue of said biological structure, wherein said tubular member induces modulated healing of said damaged biological tissue and biological structure.