Noninvasive analyzer apparatus and method of use thereof for separating distributed probing photons emerging from a sample

Abstract

A noninvasive analyzer apparatus and method of use thereof is described for spatially separating light having noninvasively probed a tissue volume into groups, which narrows standard deviations of probed tissue pathlength for each of the groups. Reduction in tissue pathlength uncertainty subsequently enhances noninvasive analyte concentration determination accuracy. Control of individual detector distance from an illumination zone in combination with control of area of a detection zone coupled to an individual detector yields intensity control of the various groups. The intensity control is optionally aided using several intensity control elements including: control of detector response shape, hardware gain settings set as function of distance from the illumination zone, varying numerical aperture of light collection optics as a function of position from the illumination zone, multiple illumination-detector linked bundlets, micro-optics, segmented spacers, arcs of detector elements, and/or outlier analysis based on detected intensity as a function of position.

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