Technique for determining particle properties

The method of claim 52, wherein the fitting includes comparing the measured dissolution time profile and the reference dissolution time profile;

• adjusting the one or more parameters based on a result of the comparison to reduce a deviation between the measured dissolution time profile and the reference dissolution time profile;
• and
• repeating the steps of determination, comparison and adjustment until the result of the comparison fulfils a matching criterion.

A computer-implemented method of assessing equivalence between a dosage form and a given second dosage form, the method comprising:

• providing a Physiologically Based Pharmacokinetic, PBPK, model;
• and
• estimating a dissolution property of particles released from the dosage form according to claim 1, wherein the measured dissolution time-profile, Mmeasured(t), is incompletely represented by one or more measured plasmatic time-profiles for the given second dosage form, and wherein the reference dissolution time-profile, M(t), is computed under conditions defined by the PBPK model.