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AssigneeExosome Diagnostics, Inc.
InventorsWayne Comper, Leileata M. Russo, Johan Karl Olov Skog
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Methods for extracting high quality nucleic acids from a heterogenous collection of nucleic acid-containing materials from a biological sample are disclosed. The heterogenous collection of nucleic-acid containing materials may contain cells or microvesicles, or both. The extractions obtained by the methods described herein are characterized by high yield and high integrity, making the extracted nucleic acids useful for various applications in which high quality nucleic acid extractions are preferred, e.g., a diagnosis, prognosis, or therapy evaluation for a medical condition.
A method of extracting nucleic acid from a biological sample, comprising the steps of:
-3. (canceled)
A nucleic acid extraction from a heterogeneous collection of nucleic acid-containing materials taken from a biological sample, wherein the heterogeneous collection of nucleic acid-containing materials comprise cells or microvesicles, and wherein the quantitative ratio of 18S rRNA to 28S rRNA detectable in the extraction is within the range of approximately 1:1 to approximately 1:2;
A nucleic acid extraction from a heterogeneous collection of nucleic acid-containing materials taken from a biological sample, wherein the heterogeneous collection of nucleic acid-containing materials comprise cells or microvesicles, and wherein the nucleic acid yield is greater than or equal to 50 pg/ml from 1 ml or 20 ml of biological sample.
(canceled)
A kit for extracting nucleic acid from a biological sample, comprising:
A kit for extracting nucleic acid from a biological sample, comprising:
Dependencies are inferred from the claim text.