Acoustic microreactor and methods of use thereof

A method of biochemically modifying support particles, comprising

• flowing a liquid medium containing suspended support particles along a flow path through a channel,
• applying an acoustic standing wave perpendicular or at an angle to the flow path and holding the suspended support particles at a point in the channel to provide held support particles,
• flowing a first reactant solution containing a first biochemical reactant through the channel and allowing the first biochemical reactant to bind with the held support particles to provide modified held support particles,
• optionally flowing a first wash solution through the channel to remove unbound first biochemical reactant,
• optionally flowing a second reactant solution containing a second biochemical reactant through the channel and allowing the second biochemical reactant to bind with the held support particles to provide further modified held support particles,
• optionally flowing a second wash solution through the channel to remove unbound second biochemical reactant, and
• releasing the modified or further modified held support particles from the acoustic standing wave for further processing.