Deoxycytidine kinase inhibitors

A compound having the formula:

• wherein:
• Y is C(R8) or N;
• Z is C(R9) or N;
• X is CH2, O, N(R10), S, S(O) or S(O)2;
• R1 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR1A, —OR1A, —NR1AR1B, —C(O)OR1A, —C(O)NR1AR1B, —NO2, —SR1A, —S(O)n1R1A, —S(O)n1OR1A, —S(O)n1NR1AR1B, —NHNR1AR1B, —ONR1AR1B, —NHC(O)NHNR1AR1B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR2A, —OR2A, —NR2AR2B, —C(O)OR2A, —C(O)NR2AR2B, —NO2, —SR2A, —S(O)n2R2A, —S(O)n2OR2A, —S(O)n2NR2AR2B, —NHNR2AR2B, —ONR2AR2B, —NHC(O)NHNR2AR2B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR3A, —OR3A, —NR3AR3B, —C(O)OR3A, —C(O)NR3AR3B, —NO2, —SR3A, —S(O)n3R3A, —S(O)n3OR3A, —S(O)n3NR3AR3B, —NHNR3AR3B, —ONR3AR3B, —NHC(O)NHNR3AR3B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR4A, —OR4A, —NR4AR4B, —C(O)OR4A, —C(O)NR4AR4B, —NO2, —SR4A, —S(O)n4R4A, —S(O)n4OR4A, —S(O)n4NR4AR4B, —NHNR4AR4B, —ONR4AR4B, —NHC(O)NHNR4AR4B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is independently hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR5A, —OR5A, —NR5AR5B, —C(O)OR5A, —C(O)NR5AR5B, —NO2, —SR5A, —S(O)n5R5A, —S(O)n5OR5A, —S(O)nNR5AR5B, —NHNR5AR5B, —ONR5AR5B, —NHC(O)NHNR5AR5B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R5 and R6 are optionally combined to form a substituted or unsubstituted cycloalkyl;
• R6 is unsubstituted C1-C6 alkyl;
• R7 is H, D, F or —CH3;
• R8 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR8A, —OR8A, —NR8AR8B, —C(O)OR8A, —C(O)NR8AR8B, —NO2, —SR8A, —S(O)n8R8A, —S(O)n8OR8A, —S(O)n8NR8AR8B, —NHNR8AR8B, —ONR8AR8B, —NHC(O)NHNR8AR8B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R9 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —COR9A, —OR9A, —NR9AR9B, —C(O)OR9A, —C(O)NR9AR9B, —NO2, —SR9A, —S(O)n9R9A, —S(O)n9R9A, —S(O)n9NR9AR9B, —NHNR9AR8B, —ONR9AR9B, —NHC(O)NHNR9AR9B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10 is H, —CH3, —C2H5, —C3H7, —CH2C6H5;
• R1A, R1B, R2A, R2B, R3A, R3B, R4A, R4B, R5A, R5B, R8A, R8B, R9A, and R9B are independently hydrogen, oxo, halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —S(O)2Cl, —S(O)3H, —S(O)4H, —S(O)2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHS(O)2H, —NHC(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• and
• n1, n2, n3, n4, n5, n8, and n9 are independently 1, 2, or 3.