Compounds, compositions and methods for the treatment of degenerative diseases and disorders

A compound of formula (II):

• wherein:
• R1 is phenyl or pyridyl;
• R2 is phenyl or pyridyl;
• R3 is phenyl or pyridyl;
• L′1 is selected from the group consisting of alkyl, amine and amide, said L′1 optionally substituted with one or more substituents independently selected from the group consisting of hydrogen, halogen, cyano, —OR101, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocycloalkyl, heteroaryl, —C(O)R101, —C(O)OR101, —C(O)NR101R102, —NR101R102, —NR101S(O)2R102, —NR101C(O)R102, —S(O)2R102, —SR101, and —S(O)2NR101R102;
• R101 and R102 are each independently selected from the group consisting of hydrogen, C3 to C20 alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocycloalkyl and heteroaryl;
• and
• wherein each R101 and R102 are independently unsubstituted or substituted with one or more substituents independently selected from the group consisting of halogen;
• hydroxyl;
• cyano;
• nitro;
• amino;
• alkylamino;
• dialkylamino;
• alkyl unsubstituted or substituted with one or more halogen or alkoxy or aryloxy;
• aryl unsubstituted or substituted with one or more halogen or alkoxy or alkyl or trihaloalkyl;
• heterocycloalkyl unsubstituted or substituted with aryl or heteroaryl or ═O or alkyl unsubstituted or substituted with hydroxyl;
• cycloalkyl unsubstituted or substituted with hydroxyl;
• heteroaryl unsubstituted or substituted with one or more halogen or alkoxy or alkyl or trihaloalkyl;
• haloalkyl;
• hydroxyalkyl;
• carboxy;
• alkoxy;
• aryloxy;
• alkoxycarbonyl;
• aminocarbonyl;
• alkylaminocarbonyl and dialkylaminocarbonyl,
• or a pharmaceutically acceptable salt thereof.