Process to manufacture n-[(3s)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide
AssigneeHoffmann-La Roche Inc.
InventorsOlaf Grassmann, Stefan Hildbrand, Roland Meier, Michelangelo Scalone, Urs Schwitter, Beat Wirz, Ulrich Zutter
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Abstract
The present invention provides processes to manufacture crystalline N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide. Also disclosed are compounds useful as intermediates in the methods of the invention.
Claims16
A crystalline form (polymorph A) of a compound of formula 1 characterized by an X-Ray
- Powder Diffraction Pattern (XRPD) having characteristic peaks expressed in values of degrees 2-theta at approximately 8.4, 15.8, 16.9, 22.9 and 24.5.
A crystalline form (polymorph B) of a compound of formula 1 characterized by an XRPD having characteristic peaks expressed in values of degrees 2-theta at approximately 15.9, 21.3, 23.6 and 26.7.
(S)-3-acetamido-N-(4-((3-fluorobenzyl)oxy)phenyl)-4-hydroxybutanamide (7).
Dependencies are inferred from the claim text.