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US 2016/0235740 A1Published application
Compositions of (-)-17-(Cyclobutylmethyl)Morphinan-3,14,-Diol
AssigneeRelmada Therapeutics, Inc.
InventorNajib BABUL
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Abstract
The present invention is directed to oral, therapeutically effective modified release pharmaceutical compositions of (−)-17-(cyclobutylmethyl)morphinan-3,14-diol and it pharmaceutically acceptable salts and the use thereof, including delayed onset and extended release dosage forms. The present invention is also directed at modified release dosage forms of oral (−)-17-(cyclobutylmethyl)morphinan-3,14-dial which provide robust efficacy and reduced potential for abuse and misuse.
Claims16
An oral dosage form comprising:
- (i) a therapeutically effective amount of butorphanol, a pharmaceutically acceptable salt thereof, or a mixture thereof, and (ii) controlled release material to release the butorphanol from the dosage form substantially only distal to the stomach following oral administration of the dosage form.
2-47. (canceled)
Dependencies are inferred from the claim text.