Devices, systems, and methods for controlled hydrodissection of vessel walls

A device for dissecting a wall of a blood vessel, the device comprising:

• an elongated tubular member having a lumen therethrough, wherein the elongated tubular member includes—
• a proximal region configured to be positioned external to a human patient and a distal region configured to be intravascularly delivered to the blood vessel and positioned within the blood vessel wall, the distal region including a slanted distal face having a proximal-most edge, a distal-most edge opposite the proximal-most edge, and an exit port positioned along the distal face between the proximal-most edge and the distal-most edge;
• and
• a guide-member positioned within the lumen and forming at least a portion of the distal face, wherein the guide-member is positioned between the exit port and the proximal-most edge of the distal face such that the exit port is offset from a central longitudinal axis of the elongated tubular member towards the distal-most edge.

A dissection assembly for separating two or more portions of a blood vessel wall, the dissection assembly comprising:

• an elongated outer member;
• a sheath positioned within the outer member;
• and
• an elongated inner member positioned within the sheath, the inner member having a beveled distal portion configured to puncture the blood vessel wall and eject a fluid into the blood vessel wall, wherein the distal portion includes a distal face and an exit port positioned along the distal face, wherein the distal face has—
• a first portion extending distally from a distal-most edge of the exit port along the distal face to a distal-most edge of the distal face,
• a second portion extending proximally from a proximal-most edge of the exit port to a proximal-most edge of the distal face, and
• wherein a length of the second portion is greater than a length of the first portion.