Immune competent models of human disease
AssigneeKansas State University Research Foundation
InventorsDeryl Troyer, Duane Davis, Stefan Bossmann
Life of this patent
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Abstract
Immunocompetent animal models having immunological tolerance to a xenograft and methods of producing the same. The animal models are tolerized to the xenograft in the pre-immune, fetal or embryonic stage, followed by transplanting the xenograft into the animal in the post-natal stage, such that the post-natal animal is immunologically tolerant to the xenograft, while remaining immunocompetent.
Claims19
A method of producing an immunocompetent animal model having immunological tolerance to a xenograft, said method comprising:
- transplanting a first xenogenic tissue into a pre-natal recipient animal, wherein said recipient animal is a pre-immune, fetal or embryonic non-human animal;
- allowing said pre-natal recipient animal to develop into a post-natal recipient animal;
- and
- transplanting a second xenogenic tissue into said post-natal recipient animal via intravenous injection of said second xenogenic tissue, wherein said second xenogenic tissue is from the same source as said first xenogenic tissue, wherein said post-natal recipient animal is immunocompetent, said post-natal recipient animal being immunologically tolerant to said xenogenic tissue, wherein when said recipient animal is a mammal said second xenogenic tissue is transplanted into said post-natal recipient animal after weaning.
An immunocompetent animal model comprising xenogenic tissue, produced according to method 1.
Dependencies are inferred from the claim text.