Methods and Apparatus for Electronic Stimulation of Tissues Using Signals That Minimize the Effects of Tissue Impedance
AssigneeCerephex Corporation
InventorJeffrey B. Hargrove
Life of this patent
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Abstract
Methods are disclosed for stimulating targeted regions of a brain to alleviate symptoms, treat conditions and/or modify brain activities associated with central sensitivity in a subject. The methods may include selecting a subject suffering from central sensitivity, identifying regions of the brain involved in central sensitivity, and stimulating one or more of these regions of the brain.
Claims21
A method for providing external electrical stimulation and treatment for a disorder by electrically stimulating and treating neurological tissue of a region of a subject's brain, the method comprising:
- generating an amplitude-modulated pulse-width modulated (AMPWM) signal, the AMPWM signal including a high frequency signal component and a low frequency signal component, in which the high frequency signal component is amplitude-modulated and pulse-width modulated and has a sufficiently high frequency to enable the AMPWM signal to penetrate high impedance portions of tissues located between an electrode and neurological tissue to be stimulated, in which the low frequency signal component is of sufficiently low frequency to provide the electrical stimulation and treatment;
- and
- transmitting the AMPWM signal from a neurostimulation device via the electrode to the neurological tissue to be stimulated.
A method for providing external electrical stimulation and treatment for a disorder by electrically stimulating and treating neurological tissue of a region of a subject's brain, the method comprising:
- determining an electrical parameter of tissues between an electrode and neurological tissue of a targeted region of a subject's brain;
- generating an amplitude-modulated pulse-width modulation (AMPWM) signal, the AMPWM signal including a high frequency signal component and a low frequency signal component, the high frequency signal component being amplitude-modulated and pulse-width modulated and having a sufficiently high frequency to enable the AMPWM signal to penetrate high impedance portions of the tissues between the electrode and the neurological tissue of the targeted region, the low frequency signal component being of sufficiently low frequency to provide electrical stimulation and treatment, and dynamically varying in frequency over time;
- generating an electrical stimulation and treatment signal from the AMPWM signal;
- applying an electrical signal with characteristics to minimize signal attenuation due to the impedance of the tissue located between the electrode and the neurological tissue of the targeted region;
- and
- transmitting the electrical stimulation and treatment signal via the electrode to the neurological tissue of the targeted region.
A neurostimulation device for providing external electrical stimulation and treatment for a disorder by electrically stimulating and treating neurological tissue of a region of a subject's brain, the system comprising:
- a signal generator for generating an amplitude-modulated pulse-width modulation (AMPWM) signal, the AMPWM signal including a high frequency signal component and a low frequency signal component, wherein the high frequency signal component is amplitude-modulated and pulse-width modulated, wherein the high frequency signal component has a sufficiently high frequency to enable the AMPWM signal to penetrate high impedance portions of tissues located between an electrode and neurological tissue to be stimulated, wherein the low frequency signal component is of sufficiently low frequency to provide the electrical stimulation and treatment, and wherein the low frequency signal component dynamically varies in frequency over time;
- and
- a transmitter that is connected between the signal generator and the electrode and transmits the AMPWM signal from the signal generator via the electrode to the neurological tissue to be stimulated.
Dependencies are inferred from the claim text.