Method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition

Use of a salt adduct comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, for the preparation of a medicament for the improvement of cognitive functions in a healthy subject.

Use according to any one of the preceding claims, wherein said carboxylated lactam ring is selected from the group consisting of:

• wherein
• R6 is selected from H, straight or branched C1-C6 alkyl optionally substituted by at least one halogen, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, cycloalkyl, aryl and heteroaryl optionally substituted by a C1-C6 alkyl;
• R7, R8, R9, R10 R11, R12, R13 and R14 are each independently selected from H, straight or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, aryl and heteroaryl optionally substituted by at least one group selected from C1-C6 alkyl, halogen, amino, cyano, nitro, thiol, C1-C6 alkoxy, aminocarbonyl, C1-C6 alkoxycarbonyl, C1-C6 carboxyalkyl, C1-C6 alkoxycarbonylalkyl and amidino.

Use according to any one of the preceding claims, wherein said salt adduct is selected from the following:

Use according to any one of the preceding claims, wherein said subject is a child, an adolescent, an adult, or an elderly person.

Use according to any one of the preceding claims, wherein said salt adduct is formulated in a sustained-, delayed or controlled-release dosage form.

Use according to any one of the preceding claims, wherein said salt adduct is formulated in a sustained-, delayed or controlled-release dosage form combined with a salt adduct formulated in an immediate or burst effect dosage form.

Use according to any one of the preceding claims, wherein said salt adduct is formulated to deliver up to 0.1-1000 mg/kg body weight/day of said salt adduct, preferably 1-400 mg/kg body weight of said salt adduct, in a single dose administration or portion thereof.

Use according to any one of the preceding claims, wherein said salt adduct is formulated together with at least one additional pharmaceutically active agent.