Process for Preparing Stealth Nanoparticles
AssigneeSinvent AS
InventorsRuth Schmid, Per Stenstad, Yrr Morch, Heidi Johnsen
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Abstract
A process for the preparation of targeting nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises, in a single step, the anionic polymerisation of an oil-in-water miniemulsion as herein defined. The invention also relates to nanoparticles produced from said process and to their use in medicine.
Claims21
1-18. (canceled)
A process for the preparation of targeting nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises, in a single step, the anionic polymerisation of an oil-in-water miniemulsion, wherein said miniemulsion comprises:
- (i) at least one alkyl cyanoacrylate monomer;
- (ii) at least two polyalkylene glycols selected from the group consisting of polyethylene glycols (PEG) and polypropylene glycols (PPG) or mixtures thereof, wherein at least one of said polyalkylene glycols is covalently attached to a targeting moiety;
- and
- (iii) optionally one or more active agents.
A process for the preparation of targeting nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, wherein said method comprises adding at least two polyalkylene glycols selected from the group consisting of polyethylene glycols (PEG) and polypropylene glycols (PPG) or mixtures thereof, to an oil-in-water miniemulsion, wherein said miniemulsion comprises
- (i) at least one alkyl cyanoacrylate monomer;
- and
- (ii) optionally one or more active agents;
- and polymerising the resulting mixture by anionic polymerisation.
A targeting nanoparticle of a poly(alkyl cyanoacrylate) homopolymer or copolymer manufactured by the anionic polymerisation of an oil-in-water miniemulsion, wherein said miniemulsion comprises
- (i) at least one alkyl cyanoacrylate monomer;
- (ii) at least two polyalkylene glycols selected from the group consisting of polyethylene glycols (PEG) and polypropylene glycols (PPG) or mixtures thereof, wherein at least one of said polyalkylene glycols is covalently attached to a targeting moiety;
- and
- (iii) optionally one or more active agents.
The targeting nanoparticle of claim 35 wherein said miniemulsion further comprises a radically polymerisable crosslinker, preferably an anhydride or an acrylate.
Dependencies are inferred from the claim text.