Anti-human trop-2 antibody having anti-tumor activity in vivo
AssigneeLivtech, Inc.
InventorsKoji NAKAMURA, Kentaro OKAMURA, Maki TAMURA, Hiroyuki YANAI, Toru KANKE
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Abstract
The present invention provides: an antibody, which specifically reacts with hTROP-2 and has anti-tumor activity in vivo; a hybridoma, which produces the aforementioned antibody; a complex of the aforementioned antibody and a drug; a pharmaceutical composition for diagnosing or treating a tumor; a method for detecting a tumor; and a kit for detecting or diagnosing a tumor.
Claims26
An antibody against human TROP-2, which has anti-tumor activity in vivo, wherein the amino acid sequences of CDR 1 to 3 of the H chain V region of the antibody are shown in SEQ ID NOS:
- 36 to 38, respectively, and/or the amino acid sequences of CDR 1 to 3 of the L chain V region of the antibody are shown in SEQ ID NOS:
- 41 to 43, respectively.
A genetically recombinant antibody against human TROP-2, which is a chimeric antibody, a humanized antibody, or a human antibody, and has anti-tumor activity in vivo, wherein the H chain V region of the chimeric antibody consists of the amino acid sequence shown in SEQ ID NO:
- 35 or the amino acid sequence consisting of amino acids at positions 20 to 134 in the amino acid sequence as shown in SEQ ID NO:
- 35, and/or the L chain V region thereof consists of the amino acid sequence shown in SEQ ID NO:
- 40 or the amino acid sequence consisting of amino acids at positions 21 to 127 in the amino acid sequence as shown in SEQ ID NO:
- 40.
A monoclonal antibody against human TROP-2, which is produced by a hybridoma having accession No. FERM BP-11251.
An antigen binding fragment derived from an antibody against human TROP-2, which has anti-tumor activity in vivo, wherein the fragment comprises the amino acid sequences shown in SEQ ID NOS:
- 36 to 38 and/or the amino acid sequences shown in SEQ ID NOS:
- 41 to 43.
A hybridoma producing a monoclonal antibody against human TROP-2, which has accession No. FERM BP-11251.
Dependencies are inferred from the claim text.