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US 2015/0329851 A1Published application
Binding a target substance
AssigneeSinvent AS
InventorsLars Kilaas, Anne Dalager Dyrli, Vidar Skagestad
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Abstract
Magnetic particles capable of binding a target substance, which comprise a magnetic material and a matrix material, wherein the magnetic material is remanent upon exposure to a magnetic field and the matrix material has a surface comprising functional groups which promote disaggregation of the particles in the presence of a liquid phase.
Claims23
-55. (canceled)
A process for separating a target substance from a sample containing the target substance, the process comprising:
- (a) providing magnetic beads in a liquid, wherein each magnetic bead includes a magnetic material coated with a matrix material, the matrix material having an affinity for the target substance, the magnetic material including one or more magnetic particles, and wherein the magnetic beads form aggregates due to remanent magnetization in the absence of a magnetic field;
- (b) disrupting the aggregates by an external force to form a dispersion of magnetic beads suspended in the liquid;
- (c) contacting the dispersion of magnetic beads with the sample containing the target substance to allow the target substance to bind to magnetic beads;
- and
- (d) extracting the magnetic beads bound to the target substance from the sample by applying a magnetic field.
2 more elements
Dependencies are inferred from the claim text.