Cancer Treatment Methods

A method for treatment of cancer selected from lung cancer, ovarian cancer, squamous cell carcinoma, pancreas exocrine cancer, malignant melanoma, gastric cancer, esophageal cancer, a metastases thereof, and leukemia, in a human or non-human body, said method comprising administrating to said body a cancer-inhibiting amount of a first compound of Formula I:

• or a physiologically acceptable salt thereof, wherein
• X is CH or N,
• each R1 independently is hydrogen or —CH2COR5;
• R5 is hydroxy, ethylene glycol, glycerol, optionally hydroxylated alkoxy, amino or alkylamido;
• each R2 independently is a group ZYR6;
• Z is a bond, CO, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R7;
• Y is a bond, an oxygen atom or a group NR6;
• R6 is a hydrogen atom, COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8, ═NR8, ═O, OP(O)(OR8)R7 and OSO3M;
• R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group;
• R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group;
• M is a hydrogen atom or one equivalent of a physiologically tolerable cation;
• R3 is a C1-8 alkylene group, a 1,2-cykloalkylene group, or a 1,2-arylene group, optionally substituted with R7;
• and
• each R4 independently is hydrogen or C1-3 alkyl.