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US 2015/0307866 A1Published application
Novel Asparaginase and Treating Diseases Associated With Asparagine Dependence
AssigneeChildren's Hospital Los Angeles
InventorDonald L. Durden
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Abstract
Disclosed herein are polypeptides which exhibit asparaginase activity and little to no glutaminase activity. The polypeptides have sequences which correspond to W. succinogenes asparaginase, but have an amino acid residue other than proline at amino acid position 121. The polypeptides exhibit higher kinetic rates of asparaginase activity to glutaminase activity as compared to W. succinogenes asparaginase and Elspar®, an E. coli asparaginase.
Claims16
An isolated and/or recombinantly produced polypeptide comprising of an amino acid sequence that corresponds to the protein having SEQ ID NO:
- 10 and has an amino acid residue other than proline at amino acid position 121, and optionally a signal sequence linked to its N-terminus.
Dependencies are inferred from the claim text.