Nts-polyplex nanoparticles system for gene therapy of cancer
OwnerRosa Angelica CASTILLO RODRIGUEZinventor
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Abstract
The present invention describes a system of gene carrier nanoparticles capable of specifically internalize into cancer cells, eg, cancer cells involved in breast cancer, in vitro and in vivo. The system described allows the introduction of therapeutic genes specifically into target cells through NSTR1 receptor-mediated endocytosis of said system, making it possible to provide treatment for this type of conditions, for example by systemic, intravenous, or in situ administration.
Claims23
A NTS-polyplex molecular complex, capable of transferring genes in vitro or in vivo into breast cancer cells that have NTSR1 receptor on their surface through its receptor-mediated endocytosis, characterized because comprise:
- a) A plasmid carrying the gene to be transfected into cancer cells;
- b) A caryophillic peptide electrostatically binded to a);
- c) Poly-L-lysine also electrostatically binded to a);
- d) Neurotensin chemically coupled to poly-L-lysine;
- e) At least one fusogenic peptide chemically coupled to poly-L-lysine;
- and
- f) Alternatively includes a tissue-specific transcriptional promoter.
Dependencies are inferred from the claim text.