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US 2015/0307533 A1Published application
Spirocyclic sulfones as gamma secretase inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsDMITRI PISSARNITSKI, ZHIQIANG ZHAO
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Abstract
Disclosed herein are compounds of Formula (I), wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.
Claims19
A compound of the Formula (I):
- wherein:
- A is a 4 to 7 membered spirocyclic ring comprising at least one heteroatom selected from the group consisting of N, O, S, S(O)2, P(O)R1, and N—S(O)2—R1, wherein the spirocyclic ring is optionally substituted with 1 to 3 substituents selected from the group consisting of C1-3alkyl and ═O;
- R1 is C1-6alkyl optionally substituted with halo;
- Each L1 is independently selected from the group consisting of 1) C1-3alkyl optionally substituted with halo, and 2) halo;
- Each L2 is independently selected from the group consisting of 1) C1-3alkyl optionally substituted with halo, and 2) halo;
- and
- n is 0 to 3.
4 more elements
A compound which is selected from the group consisting of:
Dependencies are inferred from the claim text.