3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5h)-yl) derivatives i

A compound of the general formula (I),

• wherein
• R1 represents H or F;
• X represents S or 0;
• Y1 and Y2 independently represents CH or N;
• Z1, Z2, Z3, Z4 and Z5 independently represent CH or N,
• with the proviso that 1, 2 or 3 of Z1, Z2, Z3, Z4 and Z5 represent N;
• m denotes 0, 1 or 2;
• n denotes 0, 1, 2 or 3;
• each R2 and each R3 is independently selected from the group consisting of F;
• Cl;
• Br;
• CN;
• CF3;
• CF2H;
• CFH2;
• CF2Cl;
• CFCl2;
• C1-4-alkyl;
• C(═O)—(C1-4-alkyl);
• C(═O)—NH2;
• C(═O)—N(H)(C1-4-alkyl);
• C(═O)—N(C1-4-alkyl)2;
• OH;
• O—C1-4-alkyl;
• OCF3;
• OCF2H;
• OCFH2;
• OCF2Cl;
• OCFCl2;
• NH2;
• N(H)(C1-4-alkyl);
• N(C1-4-alkyl)2;
• N(H)—C(═O)—(C1-4-alkyl);
• N(C1-4-alkyl)-C(═O)—(C1-4-alkyl);
• N(H)—S(═O)2—(C1-4-alkyl);
• N(H)—C(═O)—NH2;
• N(H)—C(═O)—N(H)(C1-4-alkyl);
• N(H)—C(═O)—N(C1-4-alkyl)(C1-4-alkyl);
• S—(C1-4-alkyl);
• S(═O)—(C1-4-alkyl);
• S(═O)2—(C1-4-alkyl);
• S(═O)2—N(H)(C1-4-alkyl);
• cyclopropyl;
• O-cyclopropyl;
• NH-cyclopropyl;
• N(H)—C(═O)-cyclopropyl;
• S(═O)-(cyclopropyl) and S(═O)2-(cyclopropyl);
• wherein the above-mentioned substituents C1-4-alkyl and cyclopropyl, may in each case be unsubstituted or substituted one or more times by identical or different substituents;
• and the above-mentioned substituent C1-4-alkyl may in each case be branched or unbranched;
• in the form of an individual stereoisomer or a mixture thereof;
• in the form of a tautomer;
• of a free compound;
• of an N-oxide;
• or in the form of a solvate and/or of a physiologically acceptable salt.