Compositions for Delivering Drugs with Low Water Solubility
AssigneeJuntech Pharmaceuticals L.L.C.
InventorJun Yang
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Abstract
The present invention provides compositions comprising polymeric micelles containing a drug with low water solubility, wherein sterol rings of pegylated sterols and the drug form a hydrophobic portion and polyethylene glycol chains of the pegylated sterols forms a hydrophilic portion. The present invention also provides methods of preparing and using such compositions for delivering drug(s) with low water solubility to a subject in need thereof.
Claims20
A composition comprising polymeric micelles containing a drug with low water solubility, wherein said polymeric micelles comprise a hydrophobic portion formed by sterol rings of pegylated sterols and the drug;
- and a hydrophilic portion formed by polyethylene glycol chains of the pegylated sterols.
A method of preparing a pharmaceutical or veterinary composition comprising polymeric micelles containing a drug with low water solubility, said method comprising:
- (a) mixing said drug with at least one pegylated sterol, or derivative thereof;
- and
- (b) subjecting the mixture to solvent evaporation, dialysis, ultrasonification, stirring, or any combination thereof to form polymeric micelles containing the drug, thereby preparing the pharmaceutical or veterinary composition.
Dependencies are inferred from the claim text.