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US 2015/0306215 A1Published application
Lprg as a chaperone of immune adjuvants
AssigneeCase Western Reserve University
InventorsClifford Harding, W. Henry Boom, Michael G. Drage, Nicole D. Pecora
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Abstract
An adjuvant combination that stimulates immune activation or response includes a hydrophobic immune adjuvant and a pathogen derived lipoprotein that chaperones the hydrophobic immune adjuvant to an immune receptor.
Claims4
A vaccine comprising:
- an antigen;
- a hydrophobic immune adjuvant;
- and
- purified non-acylated or acylated Mycobacterium tuberculosis LprG lipoprotein in an amount effective to chaperone the immune adjuvant to an immune receptor, the hydrophobic immune adjuvant being a glycolipid immune adjuvant.
1 more element
Dependencies are inferred from the claim text.