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US 2015/0306039 A1Published application
Improved nucleic acid lipid particle formulations
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsAkin AKINC, Martin MAIER, Varun KUMAR
Life of this patent
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Abstract
The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical ingredients, such as siRNA.
Claims34
Lipid nanoparticles comprising:
- (a) a biodegradable cationic lipid;
- (b) polyethylene glycol-dipalmitoylglycerol (PEG-DPG);
- (c) a non-cationic lipid (such as a neutral lipid);
- (d) optionally, a sterol;
- and
- (e) an active pharmaceutical ingredient.
3 more elements
-8. (canceled)
The lipid nanoparticles of claim 10, wherein the active pharmaceutical ingredient is a siRNA.
-13. (canceled)
(canceled)
A pharmaceutical formulation for parenteral administration comprising
- (a) lipid nanoparticles of any of the preceding claims, in
- (b) a medium, wherein the formulation has one or more of the following characteristics:
- (i) the medium is substantially free of anions,
- (ii) the medium is non-ionic or substantially non-ionic, and
- (iii) the formulation has a pH less than the pKa of the cationic lipid.
2 more elements
(canceled)
-29. (canceled)
-34. (canceled)
-39. (canceled)
-44. (canceled)
Dependencies are inferred from the claim text.