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US 2015/0305930 A1Published application
Vacuum-assisted drug delivery device and method
AssigneeSeros Medical, LLC
InventorsDavid Myung, Edward E. Manche, Donald J. Eaton, Anthony J. Abbate
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Abstract
This invention relates to a device and method for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.
Claims21
A drug delivery device, comprising:
- a vacuum source;
- and
- a drug reservoir operatively coupled to the vacuum source;
- wherein:
- the drug reservoir comprises a surface that is conformed to or is conformable with a target surface membrane of an organ to form an air-tight contact between the drug reservoir surface and the target surface membrane and wherein
- a fluid within the drug reservoir is in fluid communication with the target surface membrane when the drug reservoir surface is in contact with the target surface membrane.
3 more elements
A method for delivering a drug into an eye of a patient non-invasively for treating a disease or condition in the patient in need thereof, comprising:
- placing a surface of a drug reservoir in contact with an epithelial or conjunctival surface of the eye to which the surface of the drug reservoir has been conformed such that an air-tight contact between the drug reservoir surface and the epithelial or conjunctival surface is formed and such that a fluid in the drug reservoir is placed in fluid communication with the epithelial or conjunctival surface;
- and
- creating a vacuum within the drug reservoir to effect diffusion of the fluid in the drug reservoir through the epithelial or conjunctival surface and into the subsurface of the eye.
A device for vacuum-assisted delivery of drug to a target surface membrane of a patient in need of treatment of a disease or condition, comprising:
- a device body comprising a proximal end and a distal end having fluid communication between the proximal and distal end to allow for creation of a vacuum within the device body;
- a diffusive membrane at or near the proximal end for contacting with the target surface membrane through which a fluid comprising drug for treating the disease or condition permeates from the device to the target surface membrane when a vacuum is applied to the device,
- wherein the diffusive membrane provides support to the target surface membrane during application of the vacuum which reduces or prevents damage to the target surface membrane during application of the vacuum,
- wherein the diffusive membrane is porous to allow permeation of the fluid from the device to the target surface membrane;
- a proximal flow inhibitor mechanism that reduces or prevents proximal flow of the fluid away from the diffusive membrane during application of the vacuum;
- and
- a fluid distributer proximal to the diffusive membrane having a distal surface which provides for uniform distribution and delivery of fluid over an area of the diffusive membrane.
4 more elements
Dependencies are inferred from the claim text.