Absorbable/Biodegradable Composite Yarn Constructs and Applications Thereof
AssigneePoly-Med, Inc.
InventorsShalaby W. Shalaby, Shawn Peniston, Scott Taylor, Douglas D. Greene
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Abstract
Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
Claims26
-19. (canceled)
A biodegradable composite comprising:
- at least first and second yarn components, the yarn components having differing absorption profiles and differing strength retention profiles in the biological environment;
- wherein the first yarn component further comprises a slow absorbing component having an individual filament diameter of less than about 20 microns;
- the second yarn component comprises a fast absorbing elastomeric polymer having an individual filament diameter of greater than 20 microns;
- and
- wherein the biodegradable composite is knit as a warped mesh construct comprising the first yarn component knit in a 2-bar pattern and wherein the first yarn component and the second yarn component are initially mechanically interdependent.
A biodegradable composite comprising:
- at least first and second yarn components, the yarn components having differing absorption profiles and differing strength retention profiles in the biological environment;
- wherein the first yarn component further comprises poly-3-hydroxyalkanoate;
- and
- the second yarn component comprises a fast absorbing polyester further comprising a segmented polyaxial polymer.
The biodegradable composite of 33, wherein the poly-3-hydroxyalkanoate comprises molecular chains consisting of at least 50 percent of 3-hydroxybutyric acid-derived sequences.
A biodegradable knitted mesh comprising:
- at least first and second yarn components, the yarn components having differing absorption profiles and differing strength retention profiles in the biological environment;
- wherein the first yarn component further comprises a monofilament of a slow absorbing copolyester;
- the second yarn component comprises a monofilament of a fast absorbing copolyester;
- the first yarn component comprising a segmented polymer comprising at least 80 percent of l-lactide-based sequences;
- the second yarn component comprising a segmented copolymer comprising at least 70 percent of glycolide-based sequences;
- and
- wherein the first yarn component and the second yarn component are knit together and initially mechanically interdependent.
A biodegradable composite comprising:
- at least first and second yarn components, the yarn components having differing absorption profiles and differing strength retention profiles in the biological environment;
- the first yarn component further comprises a slow absorbing component;
- the second yarn component comprises a fast absorbing elastomeric polymer;
- the second yarn component providing initial rigidity and facile anchoring to surrounding tissue, wherein the second yarn component exhibits a breaking strength profile of about two to four weeks;
- wherein the biodegradable composite becomes more extensible as the second yarn component biodegrades;
- the first yarn component comprising a segmented polymer comprising at least 80 percent of 1-lactide-based sequences;
- the second yarn component comprising a segmented copolymer comprising at least 70 percent of glycolide-based sequences;
- and
- the biodegradable composite retains a measurable breaking strength for at least eight weeks
The biodegradable composite of claim A1, wherein the biodegradable composite is knit in a four bar pattern wherein the first yarn component is knit in a 2-bar pattern and the second yarn component is knit in a 2-bar pattern wherein the first yarn component and the second yarn component are initially mechanically interdependent.
Dependencies are inferred from the claim text.