Use of diazolidinyl urea for anti-clumping of biological samples
OwnerPavel TSINBERG, Stephen D. MIKOLAJCZYKinventors
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Abstract
The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.
Claims17
-7. (canceled)
A container for collecting biological samples comprising an effective amount of diazolidinyl urea sufficient for inhibiting cellular aggregation in combination with a non-chelating agent based anti-coagulating agent, wherein the effective amount of diazolidinyl urea is an amount that provides substantial anti-cellular-aggregation activity but insubstantial activity for preserving cells in a biological sample upon mixing with the biological sample
A container for collecting biological samples comprising an effective amount of diazolidinyl urea sufficient for inhibiting cellular aggregation, wherein the effective amount of diazolidinyl urea is an amount that provides substantial anti-cellular-aggregation activity but insubstantial activity for preserving cells in a biological sample upon mixing with the biological sample.
A container for collecting biological samples having a size from about 0.5 mL to about 50 mL and diazolidinyl urea in an amount from about 0.02 grams to about 30 grams, wherein the amount of diazolidinyl urea is an amount that provides substantial anti-cellular-aggregation activity but insubstantial activity for preserving cells in a biological sample upon mixing with the biological sample.
Dependencies are inferred from the claim text.