Specific TT Virus Sequences and Chimeric TT Virus Host Cell DNA Molecules for use in Diagnosis, Prevention and Treatment of Cancer and Autoimmunity
AssigneeDeutsches Krebsforschungszentrum
InventorsHarald zur HAUSEN, Ethel-Michele de VILLIERS
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Abstract
Described are single-stranded new sequences of TT viruses, rearranged TTV sequences and hybrid molecules of a specific TT virus sequence and host cell DNA that are capable of replicating autonomously for use in diagnosis, prevention and treatment of diseases like cancer and autoimmunity. In addition, it relates to the use of such molecules as gene vectors and artificial chromosomes.
Claims19
1-36. (canceled)
A recombinant expression vector comprising a torque teno (TT) virus polynucleic acid operably linked to prokaryotic, eukaryotic or viral transcription or translation control elements, wherein the control elements are ligated such that a desired open reading frame is expressed and the TT virus polynucleic acid comprises
- (a) one of the four nucleotide sequences of SEQ ID NOS:1-4;
- (b) a nucleotide sequence which shows 70% identity to one of the four nucleotide sequences of (a) and is capable of replicating autonomously;
- (c) a fragment of a nucleotide sequence of (a) or (b) which is capable of replicating autonomously;
- (d) a nucleotide sequence which is the complement of the nucleotide sequence of (a), (b), or (c);
- or
- (e) a nucleotide sequence which is redundant as a result of the degeneracy of the genetic code compared to any of the nucleotide sequences of (a), (b), (c) or (d).
Dependencies are inferred from the claim text.