Method for producing a composition for treating a tooth lesion
AssigneeCredentis AG
InventorsMichael Hug, Dominikus Amadeus Lysek
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Abstract
The invention relates to a method for preparing a composition for treating a tooth lesion, said composition comprising peptides that are capable of undergoing self-assembly at a certain pH. The compositions of the invention are highly suitable for being used in the medical field, in particular for remineralising a tooth lesion such as a subsurface caries lesion.
Claims20
A method for producing a composition suitable for treating a tooth lesion, comprising
- a) providing a solution comprising a peptide that starts to undergo self-assembly at a pH below 7.5, wherein said solution has a pH which is 0.1 to 0.5 pH units above the pH at which the peptide starts to undergo self-assembly;
- b) adding a compound that increases the pH of the solution to 8.0 or higher, said compound being sufficiently volatile to be removed during lyophilization;
- c) lyophilizing the solution;
- and
- d) optionally, dissolving the lyophilizate in an aqueous solution to obtain a solution with a pH that is 0.1 to 0.5 pH units above the pH at which the peptide starts to undergo self-assembly, said solution comprising the peptide predominantly in its monomeric state.
A composition in lyophilized form comprising a peptide that undergoes self-assembly at a pH value below 7.5, wherein upon reconstitution of the composition a solution with a pH that is 0.1 to 0.5 pH units above the pH at which the peptide starts to undergo self-assembly is obtained in which the peptide is predominantly present in a monomeric form.
Dependencies are inferred from the claim text.