Monoclonal antibody against d-dimer and methods of use therefor
AssigneePrinceton Biomeditech Corporation
InventorsHyun-Ju Doh, Doo-Sik Kim, Kwang-Hoe Chung
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AssigneePrinceton Biomeditech Corporation
InventorsHyun-Ju Doh, Doo-Sik Kim, Kwang-Hoe Chung
Estimating the term…
Disclosed are a monoclonal antibody against human D-dimer produced in a mouse and high molecular weight cross-linked fibrin including a corresponding epitope, a cell line secreting the monoclonal antibody, and methods for producing the same. The anti-D-dimer monoclonal antibody of the present invention may be effectively used as a diagnosis agent for screening and detecting in-vivo D-dimer, and high molecular weight cross-linked fibrin and its derivatives containing the D-dimer since the monoclonal antibody specifically reacts with D-dimer, and cross-linked fibrin and its derivatives containing the D-dimer, which do not bind to human fibrinogen or fibrin.
A monoclonal antibody that specifically reacts to D-dimer, and crosslinked fibrin or its derivatives containing D-dimer, wherein D-dimer is produced 5 by converting human fibrinogen into fibrin using an enzyme thrombin, followed by cutting fibrin using an enzyme plasmin.
Dependencies are inferred from the claim text.