Nogo Receptor Binding Protein
AssigneeBiogen Idec MA Inc.
InventorsSha Mi, John McCoy, R. Blake Pepinsky, Daniel H.S. Lee
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Abstract
The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.
Claims21
1-57. (canceled)
A method for identifying an oligodendrocyte in a tissue sample, the method comprising contacting the tissue sample with an anti-Sp35 antibody or an Sp35-binding fragment thereof and an anti-O4 oligodendrocyte marker antibody or an O4-binding fragment thereof, wherein a cell that specifically binds both the anti-Sp35 antibody or Sp35-binding fragment thereof and the anti-O4 antibody or O4-binding fragment thereof is identified as an oligodendrocyte.
A method for identifying a neuron in a tissue sample, the method comprising contacting the tissue sample with an anti-Sp35 antibody or an Sp35-binding fragment thereof and an anti-βIII tubulin neuronal marker antibody or an βIII tubulin-binding fragment thereof, wherein a cell that specifically binds both the anti-Sp35 antibody or Sp35-binding fragment thereof and the anti-βIII tubulin antibody or βIII tubulin-binding fragment thereof is identified a neuron.
A method for inhibiting the homotypic interaction of Sp35 or modulating Sp35 interaction with NgR1, the method comprising contacting Sp35 with an oligopeptide of any one of SEQ ID NOs. 10-13.
Dependencies are inferred from the claim text.