Methods for predicting whether a subject is at risk of developing a follicular lymphoma
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite D'Aix-Marseille, Centre National de la Recherche Scientifique (CNRS), Imperial College of London
InventorsKelly Rachel, Paolo Vineis, Bertrand Nadel, Sandrine Roulland
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Abstract
The present invention relates to a method for determining whether a subject is at risk of developing a FL comprising the steps consisting of i) determining the t(14:18) frequency in a blood sample obtained from the subject, ii) comparing the t(14:18) frequency determined at step i) with a predetermined reference value and iii) concluding that the subject has very high probability to develop a FL when the t(14:18) frequency determined at step i) is higher than the predetermined reference value.
Claims5
A method for determining whether a subject is at risk of developing a follicular lymphoma (FL), comprising the steps consisting of
- i) determining a t(14:18) frequency in a blood sample obtained from the subject, and
- ii) comparing the t(14:18) frequency determined at step i) with a predetermined reference value,
- and iii) concluding that the subject has very high probability to develop a FL when the t(14:18) frequency determined at step i) is equal to or higher than a predetermined reference value of 1×10−4, 2×10−4, 3×10−4, 4×10−4 or 5×10−4.
A method for determining whether a subject is in need of a prophylactic treatment to inhibit development of a follicular lymphoma (FL), comprising the steps of
- obtaining a blood sample from said subject, and
- isolating genomic DNA from leukocytes in said blood sample, and
- testing quantitatively said genomic DNA for t(14:18) translocations of BCL2/JH to determine a quantity of t(14:18) translocations per number of said leukocytes, and
- identifying said subject as being in need of a prophylactic treatment to inhibit development of a FL when said quantity of t(14:18) translocations exceeds 1×10−4.
A method for treating a subject at risk for development of a follicular lymphoma (FL), comprising the steps of
- obtaining a blood sample from said subject, and
- isolating genomic DNA from leukocytes in said blood sample, and
- testing quantitatively said genomic DNA for t(14:18) translocations of BCL2/JH to determine a quantity of t(14:18) translocations per number of said leukocytes, and
- identifying said subject as being in need of treatment to inhibit development of a FL when said quantity of t(14:18) translocations exceeds 1×10−4, and
- treating said subject with at least one treatment selected from the group consisting of B-cell depletion, radiation therapy and chemotherapy.
Dependencies are inferred from the claim text.