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US 2015/0175972 A1Published application
Three dimensional matrix for cancer stem cells
AssigneeUniversity of South Carolina
InventorEsmaiel Jabbari
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AssigneeUniversity of South Carolina
InventorEsmaiel Jabbari
Estimating the term…
Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.
A method of forming a three dimensional hydrogel matrix for supporting a cancer cell, the method comprising:
A three dimensional hydrogel matrix comprising a crosslinked inert synthetic polymer and a peptide conjugated to the matrix, the peptide affecting the growth, development, and/or proliferation of a cancer stern cell, the three dimensional hydrogel matrix having a predetermined elastic modulus.
A method for studying a cell population, the method comprising:
Dependencies are inferred from the claim text.