Generating hepatocytes
AssigneesThe J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Glads, The Regents of the University of California
InventorsSaiyong Zhu, Sheng Ding, Holger Willenbring, Milad Rezvani, Jack Harbell
Life of this patent
Estimating the term…
Abstract
Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.
Claims33
A composition comprising an epidermal growth factor (EGF), a basic fibroblast growth factor (bFGF), an activator of WNT signaling, a nuclear receptor liver receptor homolog 1 agonist, a histone deacetylase (HDAC) inhibitor, a histone demethylase LSD1 inhibitor, a DNA methyltransferase (DNMT) inhibitor, or any a combination thereof.
A composition comprising an activator of WNT signaling, a nuclear receptor liver receptor homolog 1 agonist, a histone deacetylase (HDAC) inhibitor, a histone demethylase LSD1 inhibitor, a DNA methyltransferase (DNMT) inhibitor, Activin A, or any combination thereof.
A composition comprising epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and a TGF-beta inhibitor.
A composition comprising basic fibroblast growth factor (bFGF), a TGF-beta inhibitor, bone morphogenetic protein 4 (BMP4), and dexamethasone.
A composition comprising a TGF-beta inhibitor, hepatocyte growth factor, a Notch inhibitor, oncostatin M (OSM), or any combination thereof.
Dependencies are inferred from the claim text.