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US 2015/0175712 A1Published application
Antagonist to an enzyme and/or a metabolite of the kynurenine pathway
AssigneeImmusmol SAS
InventorAlban Bessède
Life of this patent
Estimating the term…
Abstract
The present invention relates to a modulator of an enzyme and/or a metabolite of the kynurenine pathway (FIG. 18).
Claims18
1-37. (canceled)
A monoclonal antibody or an antigen-binding fragment thereof, wherein the antibody is directed against a metabolite of the kynurenine pathway, said metabolite is selected from the group consisting of 3-Hydroxy Anthranilic Acid (3HAA), Kynurenine, Cinnabarinic Acid, and Quinolinic Acid.
A method of treating a neoplastic disease in a human or animal patient in need of such treatment, said method comprising:
- administering to the patent a modulator of the kynurenine pathway,
- thereby reducing the formation, concentration, availability, or effect of at least one of:
- 3-Hydroxy Anthranilic Acid (3HAA), L-Kynurenine, Quinolinic Acid, Cinnabarinic Acid, and Kynureninase.
Dependencies are inferred from the claim text.