Humanized antibodies to cluster of differentiation 3 (cd3)

A monoclonal antibody (mAb), or fragment thereof, that binds specifically to Cluster of Differentiation 3 (CD3), wherein said antibody comprises:

• i. a humanized framework comprising the mutations (using Kabat numbering system) Q5V, A9S, A12K, 13K, K38R, R40A, Q43K, K66R, S75T, T83R, S87T, T108L and L109V relative to the sequence of the heavy (H) chain variable (V) region set forth in SEQ ID NO:
• 7 and the mutations H OT, M1 1L, A13L, K18R, V19A, T22S, S40P, T42K, S43A, A60S, H61R, S70D, S72T, G77S, M78L, E79Q, A80P, A83F, S100G, L104V and N107K relative to the sequence of the light kappa (κ) chain V region set forth in SEQ ID NO:
• 8;
• and ii. the six CDRs set forth in SEQ ID NOs:
• 1-6.