Heteroaryls and uses thereof

A compound of formula IA or IB:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is —C(O)N(R3)2, —C(O)(NH)OH, —C(═NH)NHOH, —C(O)NR3N(R3)2, —C(═N—NH2)NH2, or —C(═N)N(R3)2;
• each occurrence of R3 is independently hydrogen or an optionally substituted C1-6aliphatic;
• Ring A is a group selected from 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each occurrence of R2 is independently R12a, -T2-R12d, or —V2-T2-R12a, and:
• each occurrence of R12a is independently halogen, —CN, —NO2, —R12c, —N(R12b)2, —OR12b, —SR12c, —S(O)2R12c, —C(O)R12b, —C(O)OR12b, —C(O)N(R12b)2, —S(O)2N(R12b)2, —OC(O)N(R12b)2, —N(R12e)C(O)R12b, —N(R12e)SO2R12c, —N(R12e)C(O)OR12b, —N(R12e)C(O)N(R12b)2, or N(R12e)SO2N(R12b)2, or two occurrences of R12b, taken together with a nitrogen atom to which they are bound, form an optionally substituted 4-7-membered heterocyclyl ring having 0-1 additional heteroatoms selected from nitrogen, oxygen, and sulfur;
• each occurrence of R12b is independently hydrogen or an optionally substituted group selected from C1-C6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, 6-10-membered aryl, and 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each occurrence of R12c is independently an optionally substituted group selected from C1-C6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, 6-10-membered aryl, and 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each occurrence of R12d is independently hydrogen or an optionally substituted from 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each occurrence of R12e is independently hydrogen or an optionally substituted C1-6 aliphatic group;
• each occurrence of V2 is independently —N(R12e)—, —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)O—, —C(O)N(R12e)—, —S(O)2N(R12e)—, —OC(O)N(R12e)—, N(R12e)C(O)—, —N(R12e)SO2—, —N(R12e)C(O)O—, —N(R12e)C(O)N(R12e)—, —N(R12e)SO2N(R12e)—, —OC(O)—, or —C(O)N(R12e)—O—;
• and
• T2 is an optionally substituted C1-C6 alkylene chain wherein the alkylene chain optionally is interrupted by —N(R13)—, —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)O—, —C(O)N(R13)—, —S(O)2N(R13)—, —OC(O)N(R13)—, —N(R13)C(O)—, —N(R13)SO2—, —N(R13)C(O)O—, —N(R13)C(O)N(R13)—, —N(R13)S(O)2N(R13)—, —OC(O)—, or —C(O)N(R13)—O— or wherein T2 or a portion thereof optionally forms part of an optionally substituted 3-7 membered cycloaliphatic or heterocyclyl ring, wherein R13 is hydrogen or an optionally substituted C1-4aliphatic group;
• n is 0 to 4;
• W is selected from —C(R7)2—, —C(═C(R7)2)—, —C(R7)2O—, —C(R7)2NR7a—, —O—, —N(R7b)—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)NR7a—, and —N(R7a)C(O)—, wherein:
• each occurrence of R7 is independently hydrogen, or an optionally substituted group selected from C1-6 aliphatic, 6-10-membered aryl, 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, —N(R7b)2, —OR7a, —SR7a, halo, and —CN;
• each occurrence of R7a is independently hydrogen or optionally substituted C1-6 aliphatic or optionally substituted C3-6 cycloaliphatic;
• each occurrence of R7b is independently hydrogen, optionally substituted C1-6 aliphatic, optionally substituted C3-6 cycloaliphatic, —C(O)R7a, —C(O)OR7a, S(O)R7a, or —S(O)2R7a;
• or
• wherein any two occurrences of R7, R7a, or R7b taken together with the atom to which they are bound, form an optionally substituted group selected from a 3-6-membered cycloaliphatic ring, 6-10-membered aryl, 3-6-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• or wherein any two occurrences of R7a and R2, or R7b and R2 taken together with the nitrogen atom to which they are bound, form an optionally substituted group selected from 3-6-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• G1 is N;
• and
• HY is
• wherein each occurrence of R14 is independently —R14a or -T1-R14d, wherein:
• each occurrence of R14a, as valency and stability permit, is independently fluorine, ═O, ═S, —CN, —NO2, —R14c, N(R14b)2, —OR14b, SR14c, —S(O)2R14c, —C(O)R14b, —C(O)OR14b, —C(O)N(R14b)2, —S(O)2N(R14)2, —OC(O)N(R14)2, —N(R14e)C(O)R14b, —N(R14e)SO2R14c, —N(R14e)C(O)OR14b, —N(R14e)C(O)N(R14b)2, or —N(R14e)SO2N(R14b)2, or two occurrences of R14b, taken together with a nitrogen atom to which they are bound, form an optionally substituted 4-7-membered heterocyclyl ring having 0-1 additional heteroatoms selected from nitrogen, oxygen, and sulfur;
• each occurrence of R14b is independently hydrogen or an optionally substituted group selected from C1-C6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, 6-10-membered aryl, and 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each occurrence of R14c is independently an optionally substituted group selected from C1-C6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, 6-10-membered aryl, and 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each occurrence of R14d is independently hydrogen or an optionally substituted from 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each occurrence of R14e is independently hydrogen or an optionally substituted C1-6 aliphatic group;
• and
• T1 is an optionally substituted C1-C6 alkylene chain wherein the alkylene chain optionally is interrupted by —N(R14a)—, —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)O—, —C(O)N(R14a)—, —S(O)2N(R14a)—, —OC(O)N(R14a)—, —N(R14a)C(O)—, —N(R14a)SO2—, —N(R14a)C(O)O—, —NR14aC(O)N(R14a)—, —N(R14a)S(O)2N(R14a)—, —OC(O)—, or —C(O)N(R14a)—O— or wherein T1 or a portion thereof optionally forms part of an optionally substituted 3-7 membered cycloaliphatic or heterocyclyl ring;
• n is 0-6;
• m is 1 or 2;
• p is 0, 1, or 2.