US 2015/0175557 A1 · SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith

AssigneeSignal Pharmaceuticals, LLC

InventorsPatrick Papa, Brian Edwin Cathers, Andrew Antony CALABRESE, Brandon Wade WHITEFIELD, Brydon BENNETT, Daniel CASHION, Deborah MORTENSEN, Dehua HUANG, Eduardo TORRES, Jason PARNES, John SAPIENZA, Joshua HANSEN, Katerina LEFTHERIS, Matthew CORREA, Maria Mercedes DELGADO, Neil RAHEJA, Sami BAHMANYAR, Sayee HEGDE, Stephen NORRIS, Veronique PLANTEVIN-KRENITSKY

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Abstract

Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

Claims34

Dependent claims

A compound of formula (I):

or a pharmaceutically acceptable salt, tautomer, isotopologue, or stereoisomer thereof,
wherein:
X is CN or CF3;
L is (C1-4 alkyl);
R1 is substituted or unsubstituted heteroaryl;
and
R2 is substituted or unsubstituted cycloalkyl.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/576,197Filed 19 Dec 2014

Priority

20 Dec 2013

Published

25 Jun 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification34 codes

C07D 239/48
Two or more oxygen, sulphur or nitrogen atoms: two nitrogen atoms
A61K 31/505
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: pyrimidines; Hydrogenated…
A61K 31/506
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: not condensed and containing further heterocyclic rings
A61K 31/5377
1,4-Oxazines, e.g. morpholine: not condensed and containing further heterocyclic rings, e.g. timolol