Amino acid derivatives and absorbable polymers therefrom
AssigneeBezwada Biomedical, LLC
InventorRao S. Bezwada
Life of this patent
Estimating the term…
Abstract
The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.
Claims21
1-18. (canceled)
A medical or surgical article, comprising a polymer formed from a monomer of formula N or V:
- wherein:
- R″ is selected from:
- alkyl, aryl, and arylalkyl-, wherein:
- (a) the alkyl moiety has from 1-36 carbon atoms;
- (b) one or more —CH2— groups of the alkyl moiety are replaced by —O—, —S—, or an ester group, wherein the ester group is selected from low molecular weight polyesters and polyethers;
- and,
- (c) the alkyl and aryl groups are optionally substituted with one or more lower alkyl groups;
- alternatively, R″ is a biologically active substance
- wherein the medical or surgical article is selected from:
- drug delivery systems, tissue adhesives, tissue engineering, bone wax formulations, stent coatings, stents, porous devices, implantable medical devices, molded articles, wound closure devices, coatings, fibers or filaments, ligatures, needles, films, knitted products, foodstuffs, nutritional supplements, nutriceuticals, cosmetics, pharmaceuticals, biodegradable chewing gums, flavors, controlled drug delivery systems, solvents for drugs, foams, orthopedic devices, surface modifying agents, wound and/or burn dressings or coverings, and degradable containers and packaging materials.
Dependencies are inferred from the claim text.