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US 2015/0174231 A1Published application
Combination neisserial compositions
AssigneeNovartis AG
InventorsMarzia Monica GIULIANI, Mariagrazia PIZZA, Rino RAPPUOLI
Life of this patent
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Abstract
Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.
Claims10
1:
- A composition comprising (i) a first substantially purified polypeptide comprising a fragment of SEQ ID NO:
- 3518, wherein the fragment of SEQ ID NO:
- 3518 includes 8 or more contiguous amino acids from SEQ ID NO:
- 3518;
- and (a) a second substantially purified polypeptide comprising a second fragment of SEQ ID NO:
- 3926, wherein the fragment of SEQ ID NO:
- 3926 includes 8 or more contiguous amino acids from SEQ ID NO:
- 3926.
5 more elements
2:
- The composition of claim 1 wherein the fragment of SEQ ID NO:
- 3518 includes 14 or more contiguous amino acids from SEQ ID NO:
- 3518;
- and the fragment of SEQ ID NO:
- 3926 includes 14 or more contiguous amino acids from SEQ ID NO:
- 3926.
3 more elements
3:
- The composition of claim 1, wherein the first or second substantially purified polypeptide is a fusion protein.
4:
- The composition of claim 3, wherein the fusion protein comprises a GST protein or a HIS-tag.
5:
- The composition of claim 2, wherein the first or second substantially purified polypeptide is a fusion protein.
6:
- The composition of claim 3, wherein the first or second substantially purified polypeptide is a fusion protein.
7:
- The composition of claim 1, further comprising an adjuvant.
8:
- The composition of claim 2, further comprising an adjuvant.
9:
- The composition of claim 7, wherein the adjuvant comprises an aluminum salt.
10:
- The composition of claim 8, wherein the adjuvant comprises an aluminum salt.