Compositions and methods for wound healing and tissue repair
AssigneesUniversity of South Carolina, MUSC Foundation for Research Development
InventorsRobert G. Gourdie, Edie C. Goldsmith, L. Jane Jourdan, Joshua Matthew Rhett, Michael J. Yost
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Abstract
Provided are peptides that can inhibit collagen synthesis, processing and/or secretion from scar forming cells or fibroblasts. Also provided are methods for using the peptides to produce an anti-fibrotic, anti-scarring, anti-inflammatory, and/or pro-regenerative effect, e.g., on an injured or diseased tissue.
Claims32
An isolated peptide, wherein the peptide is less than 50 amino acids in length and comprises JM1 (SEQ ID NO:1) or JM2 (SEQ ID NO:2), or a sequence having at least 90% sequence identity to JM1 (SEQ ID NO:1) or JM2 (SEQ ID NO:2).
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