Trkb agonists and methods of use

A method of treating of treating depression comprising administering, to a subject in need thereof, an effective amount of a compound Formula F,

• or salts or prodrugs thereof wherein,
• X is hydrogen, dialkylamino, or heterocyclyl, wherein X is optionally substituted with one or more, the same or different R8;
• R2 is hydrogen, alkoxy, hydroxy, or alkanoyloxy, wherein R2 is optionally substituted with one or more, the same or different R8;
• R3 is hydrogen, alkoxy, hydroxy, dialkylamino, or alkanoyloxy, wherein R3 is optionally substituted with one or more, the same or different R8;
• R4 is hydrogen or halogen;
• R5 is hydrogen, alkoxy, hydroxy, or alkanoyloxy wherein R5 is optionally substituted with one or more, the same or different R8;
• and
• R8 is alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl)2amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R8 is optionally substituted with one or more, the same or different, R9;
• R9 is halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl;
• and
• R10 and R11 are each, the same or different hydrogen, alkyl, or alkanoyl.