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US 2015/0174070 A1Published application
Liposome suspensions, method for preparing the same, and application thereof
AssigneePharmosa Limited
InventorsMei-Ling Cheng, Yao-Kun Huang
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Abstract
A method for preparing the liposome suspensions comprising liposomes with small particle size and uniform particle size distribution by performing an injection process in combination with a one-step extrusion, and further the liposome suspensions obtainable by this method as well as drug-encapsulating liposomes as well as a system for preparing the said liposome suspensions are disclosed.
Claims18
A method for preparing liposome suspensions comprising:
- (1) providing a component comprising phospholipid, cholesterol or cholesterol salt derivatives, and polyethylene glycol derivatives, wherein the molar ratio of the phospholipid to the cholesterol or the cholesterol salt derivatives to the polyethylene glycol derivatives is 3-50:1-50:1;
- (2) mixing the component with an alcoholic solvent to form a mixture, wherein concentration of the mixture is between 2 mM and 300 mM;
- and
- (3) injecting the mixture into an aqueous solution under thermal condition with an injection apparatus followed by stirring to form the liposome suspensions, wherein the volume ratio of the mixture to the aqueous solution is between 1:2 and 1:500.
1 more element
Dependencies are inferred from the claim text.