Sonolysis method
AssigneeDoheny Eye Institute
InventorMark S. Humayun
Life of this patent
Estimating the term…
Abstract
Devices, systems, kits and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ultrasound probe, such as an ocular probe for use in sonolysis, is disclosed that is for use in the eye and is configured to provide ultrasound with a frequency of between about 1.0 and about 3.0 MHz and with a mechanical index of between about 0.2 and about 0.6 MI. The probes, kits and systems are configured for delivery of ultrasound to the eye to activate microbubbles located at a site of a blockage within an ocular blood vessel to improve blood flow to an area of the eye.
Claims15
An ocular sonolysis probe comprising a housing and at least one transducer element contained within the housing, wherein the transducer element provides ultrasound energy at a frequency of between about 1.0 and about 3.0 MHz and a mechanical index of between about 0.2 and about 0.6 MI.
An ocular ultrasound probe comprising a housing and at least one transducer element contained within the housing, wherein the housing is flat or elongated, and wherein the elongated housing comprises a distal end comprising a probe head, and wherein the shape of the flat housing or the probe head is a half-circle, a crescent, a wedge or a ring.
An intraocular ultrasound probe comprising a housing and at least one transducer element contained within the housing, wherein the transducer element provides ultrasound energy at a frequency of between about 1.0 and about 3.0 MHz and a mechanical index between about 0.2 and about 0.6 MI.
A method of treating a disease or disorder of ocular blood flow, comprising supplying a microbubble composition to the eye and applying ultrasound energy to the eye using an ultrasound probe, wherein the ultrasound energy has a frequency of between about 1.0 and about 3.0 MHz and a mechanical index of between about 0.2 and about 0.6 MI.
Dependencies are inferred from the claim text.