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US 2015/0173357 A1Published application
Modulating germination of paenibacillus larvae
AssigneeThe Board of Regents of the Nevada System of Higher Education, on Behalf of the University of
InventorErnesto Abel-Santos
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Abstract
Materials and methods for stimulating or inhibiting germination of Paenibacillus larvae spores, including methods for inhibiting P. larvae germination to reduce foulbrood in honey bees.
Claims30
A method for preventing germination of a Paenibacillus larvae spore, comprising contacting said spore with:
- (a) a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- each R is independently selected from the group consisting of:
- substituted or unsubstituted (C1-C6)alkyl;
- substituted or unsubstituted (C2-C6)alkenyl;
- substituted or unsubstituted (C2-C6)alkynyl;
- halo;
- (C1-C6)haloalkyl;
- ORA;
- CORA;
- COORA;
- OCORA;
- CN;
- NO2;
- NRARB;
- and NRACORB;
- each RA and RB are independently selected from the group consisting of H and (C1-C6)alkyl;
- and
- n is an integer from 0 to 6;
- or
- (b) a compound of Formula (II):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is selected from the group consisting of H and (C1-C6)alkyl;
- each R2 is independently selected from the group consisting of:
- substituted or unsubstituted (C1-C6)alkyl;
- substituted or unsubstituted (C2-C6)alkenyl;
- substituted or unsubstituted (C2-C6)alkynyl;
- halo;
- (C1-C6)haloalkyl;
- ORA;
- CORA;
- COORA;
- OCORA;
- CN;
- NO2;
- NRARB;
- and NRACORB;
- each RA and RB are independently selected from the group consisting of H and (C1-C6)alkyl;
- and
- n is an integer from 0 to 5;
- wherein said spore is contacted with said compound in an amount effective to prevent germination of said spore.
40 more elements
A composition comprising a carrier and:
- (a) a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- each R is independently selected from the group consisting of:
- substituted or unsubstituted (C1-C6)alkyl;
- substituted or unsubstituted (C2-C6)alkenyl;
- substituted or unsubstituted (C2-C6)alkynyl;
- halo;
- (C1-C6)haloalkyl;
- ORA;
- CORA;
- COORA;
- OCORA;
- CN;
- NO2;
- NRARB;
- and NRACORB;
- each RA and RB are independently selected from the group consisting of H and (C1-C6)alkyl;
- and
- n is an integer from 0 to 6;
- or
- (b) a compound of Formula (II):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is selected from the group consisting of H and (C1-C6)alkyl;
- each R2 is independently selected from the group consisting of:
- substituted or unsubstituted (C1-C6)alkyl;
- substituted or unsubstituted (C2-C6)alkenyl;
- substituted or unsubstituted (C2-C6)alkynyl;
- halo;
- (C1-C6)haloalkyl;
- ORA;
- CORA;
- COORA;
- OCORA;
- CN;
- NO2;
- NRARB;
- and NRACORB;
- each RA and RB are independently selected from the group consisting of H and (C1-C6)alkyl;
- and
- n is an integer from 0 to 5.
39 more elements
A method for reducing germination of Paenibacillus larvae spores in honey bee larvae, comprising administering to said honey bee larvae a composition comprising:
- (a) a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- each R is independently selected from the group consisting of:
- substituted or unsubstituted (C1-C6)alkyl;
- substituted or unsubstituted (C2-C6)alkenyl;
- substituted or unsubstituted (C2-C6)alkynyl;
- halo;
- (C1-C6)haloalkyl;
- ORA;
- CORA;
- COORA;
- OCORA;
- CN;
- NO2;
- NRARB;
- and NRACORB;
- each RA and RB are independently selected from the group consisting of H and (C1-C6)alkyl;
- and
- n is an integer from 0 to 6;
- or
- (b) a compound of Formula (II):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1l is selected from the group consisting of H and (C1-C6)alkyl;
- each R2 is independently selected from the group consisting of:
- substituted or unsubstituted (C1-C6)alkyl;
- substituted or unsubstituted (C2-C6)alkenyl;
- substituted or unsubstituted (C2-C6)alkynyl;
- halo;
- (C1-C6)haloalkyl;
- ORA;
- CORA;
- COORA;
- OCORA;
- CN;
- NO2;l NRARB;
- and NRACORB;
- each RA and RB are independently selected from the group consisting of H and (C1-C6)alkyl;
- and
- n is an integer from 0 to 5;
- wherein said composition is administered in an amount effective to reduce germination of P. larvae spores in said honey bee larvae.
39 more elements
Dependencies are inferred from the claim text.