Method of rapidly producing improved vaccines for animals

A method of protecting a second animal from a biotype of a microorganism, the method comprising,

• a) identifying a nucleic acid molecule of interest or fragment thereof (NOI) of a microorganism, said NOI capable of producing a protective response in the same species as the second animal;
• b) obtaining a biological sample from at least one first animal where said first animal has been exposed to said biotype of said microorganism;
• c) obtaining from said sample said NOI of said microorganism without the need to isolate said microorganism;
• d) producing a protective molecule from said NOI, said protective molecule, selected from the group consisting of:
• (i) a polypeptide or fragment thereof expressed by said NOI;
• and
• (ii) a RNA particle comprising or producing (i);
• e) producing a vaccine comprising said protective molecule, wherein said protective molecule does not comprise said microorganism or a replicable or living pathogenic microorganism;
• f) providing said protective molecule in an amount that when administered to said second animal protects said second animal from said biotype of said microorganism;
• g) administering said protective molecule to at least one said second animal;
• and
• h) producing a protective response specific to said biotype of said microorganism in said second animal.