Sodium channel blocker delivery system with scleral lens
AssigneeBoston Foundation for Sight
InventorPerry ROSENTHAL
Life of this patent
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Abstract
A scleral lens is provided with a sodium channel blocker or a sodium channel modulator disposed in the pre-corneal tear film between the scleral lens and the cornea. This system can be used to deliver sodium channel blockers or a sodium channel modulators not currently used because of poor bioavailability. Methods of using this sodium channel blocker delivery system or a sodium channel modulator delivery system are also disclosed.
Claims22
A method of treating corneal neuropathic pain in the eye of a patient, the method comprising:
- applying to the eye of a patient suffering from corneal neuropathic pain, a sodium channel modulator delivery system adapted for treatment of corneal neuropathic pain comprising:
- (a) a scleral lens to be disposed on an eye of a patient, the scleral lens comprising:
- an optic portion having a first curvature, and a scleral portion having a second curvature, wherein:
- (i) the first curvature is adapted to cover a cornea of the eye creating a reservoir between the first curvature and the cornea without any contact between the first curvature and the cornea, and
- (ii) the second curvature is adapted to align with the shape of a sclera of the eye, on which the second curvature rests;
- and
- alternating the administration of a solution comprising lacosamide with the administration of a solution comprising at least one of bupivacaine, lidocaine, proparacaine, flecainide, tetracaine, ropivacaine, levobupivacaine, carbamazepine, and amitriptyline at an alternation interval.
A method of increasing the bioavailability of a sodium channel modulator at the eye of a person, the method comprising the steps of
- applying a solution comprising a sodium channel modulator to the eye of a person;
- applying a scleral lens on the eye of the patient, such that an optic portion of the lens having a first curvature covers a cornea of the eye and creates a reservoir for the solution between the first curvature and the cornea without any contact between the first curvature and the cornea and a scleral portion of the lens having a second curvature aligns with the shape of a sclera of the eye, on which the second curvature rests.
A sodium channel modulator delivery system for increasing the bioavailability of a sodium channel modulator at the eye of a person comprising:
- (a) a scleral lens to be disposed on an eye of a patient, the scleral lens comprising:
- an optic portion having a first curvature, and a scleral portion having a second curvature, wherein:
- (i) the first curvature is configured to cover a cornea of the eye to create a reservoir between the scleral lens and the cornea without any contact between the scleral lens and the cornea, and
- (ii) the second curvature is shaped to rest on a sclera of the eye;
- and
- (b) a solution comprising a sodium channel modulator.
Dependencies are inferred from the claim text.